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1 article(s) from Lin, Shuo

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Chao Che,
Song Li,
Bo Yang,
Shengchang Xin,
Zhixiong Yu,
Taofeng Shao,
Chuanye Tao,
Shuo Lin and
Zhen Yang

Beilstein J. Org. Chem. 2012, 8, 841–849, doi:10.3762/bjoc.8.94

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Figure 1: Structures of Smo antagonists and agonists.

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Scheme 1: General synthetic route for Sant-75. Reagents and conditions: (a) Pd(PPh₃)₄, PhMe, Na₂CO₃, H₂O, 85 ...

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Scheme 2: Substituent-modifications on the motif A. Reagents and conditions: (a) CH₂Cl₂, Et₃N; (b) CH₂Cl₂, TF...

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Scheme 3: Substituent-modifications on the motif A. Reagents and conditions: (a) (i) FeCl₃, Zn, H₂O, DMF, 100...

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Scheme 4: Core modification on the motif A. Reagents and conditions: (a) BOP, DIEA, DMF; (b) CH₂Cl₂, TFA.

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Figure 2: Core modification on the motif B.

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Scheme 5: Synthesis of key intermediate biaryl aldehydes. Reagents and conditions: (a) Pd(OAc)₂, PPh₃, 1,4-di...

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Scheme 6: Chemical modifications on the motif C. Reagents and conditions: (a) Pd(OAc)₂, PPh₃, 1,4-dioxane, Na₂...

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Scheme 7: Chemical modifications on the motif D. Reagents and conditions: (a) R²COCl, CH₂Cl₂.

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Published 06 Jun 2012

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